A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

Mark S. Aloia, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Clive Ballard: Wolfson Research Centre, University of Newcastle upon Tyne, Newcastle, UK Patricia A. Boyle, PhD: Department of Neurology, Boston University School of Medicine, Boston, MA Adam M. Brickman, MPhil: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Jeffrey Browndyke, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Deborah Cahn-Weiner, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Ronald Cohen, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Anelyssa D'Abreu, MD: Department of Clinical Neurosciences, Brown Medical School, Providence, RI Jennifer Duncan Davis, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sophie Desbiens, BS: Department of Biomedical Engineering, Boston University, MA John E. Donahue, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI Timo Erkinjuntti, MD: Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Finland Margaret M. Esiri, MD: Department of Clinical Neurology, University of Oxford; Department of Neuropathology, Oxford Radcliffe NHS Trust, UK Marc Fisher, MD: Department of Neurology, University of Massachusetts Medical School, Worcester Kelly D. Garrett, PhD: Utah State University, Logan Serge Gauthier, MD: MCSA Alzheimer's Disease Research Unity, McGill Center for Studies on Aging, McGill University, Montreal, Canada Paula Grammas, PhD: Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City John Gunstad, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Vladimir Hachinski, MD, FRCP(C), DSC: Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada Ebrahim Haroon, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Angela Lee Jefferson, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Kurt A. Jellinger, MD: Institute of Clinical Neurobiology and University of Vienna, Austria Elizabeth M. Jonak, PhD: Yerkes National Primate Center, Emory University, Atlanta, GA Raj Kalaria: Wolfson Research Center, University of Newcastle upon Tyne, UK Jason E. Kanz, PhD: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City Rose Anne Kenny: Wolfson Research Center, University of Newcastle upon Tyne, UK George A. Kuchel, MD: University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington Anand Kumar, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Kelly L. Lange, MD: Department of Psychology, San Diego State University and Department of Psychiatry, School of Medicine, University of California at San Diego Helen Lavretsky, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine David J. Libon, PhD: Department of Psychiatry, Center for Aging, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford Lewis A. Lipsitz, MD: Division on Aging, Harvard Medical School, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, MA Jose G. Merino, MD, MPhil: Department of Neurology, University of Florida, Shands Jacksonville William P. Milberg, PhD: Department of Psychiatry, Harvard Medical School and West Roxbury Department of Veteran Affairs Medical Center, Boston, MA David J. Moser, PhD: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA Mark B. Moss, PhD: Department of Anatomy and Neurobiology and Department of Neurology, Boston University School of Medicine, Boston, MA and Yerkes National Primate Center, Emory University, Atlanta, GA Dan Mungas, PhD: Department of Neurology, University of California at Davis, Sacramento Zsuzsanna Nagy, MD: Department of Pharmacology, University of Birmingham, UK Brian R. Ott, MD: Department of Clinical Neurosciences, Brown Medical School, Providence, RI Robert H. Paul, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Dana L. Penney, PhD: Department of Neurology, Lahey Clinic, Burlington, MA Rebecca E. Ready, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Kenneth Rockwood, PhD: Geriatric Medicine Research Unit, Queen Elizabeth II Health Science Center, Dalhousie University, Halifax, Nova Scotia, Canada Gustavo C. Roman, MD: Geriatric Research Education and Clinical Center, Department of Neurology, University of Texas Health Science Center at San Antonio and the Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio Stephen Salloway, MD, MS: Departments of Clinical Neurosciences and Psychiatry and Human Behavior, Brown Medical School; Department of Neurology, Butler Hospital, Providence, RI Stephen Scheinthal, DO: Department of Psychiatry, Center for Aging, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford Magdy Selim, MD, PhD: Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA Jorge M. Serrador, PhD: Division on Aging, Harvard Medical School, Beth Isreal Deaconess Medical Center, Boston, MA Mary Beth Spitznagel, MS: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sally Stephens: Wolfson Research Center, University of Newcastle Upon Tyne, UK Edward G. Stopa, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI Lawrence Sweet, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Rod Swenson, PhD: Department of Neuroscience, University of North Dakota School of Medicine, Grand Fords, ND David F. Tate, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Geoffrey Tremont, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sharon X. C. Yang, MD: University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington Brian D. Zipser, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI