The Pigmentary System: Physiology and Pathophysiology, 2nd Edition
by Editor: James J. Nordlund (Group Health Associates, Cincinnati, OH); Editor: Raymond E. Boissy (Univ. of Cincinnati College of Medicine, Cincinnati, OH); Editor: Vincent J. Hearing (Laboratory of Cell Biology, NIH, Bethesda, MD); Editor: RichardFormat: eBook
Pub. Date: 2008-06-01
Publisher(s): Wiley-Blackwell
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Summary
The most comprehensive and integrated book on pigmentation The Pigmentary System, Second Edition, gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes. New features of this Second Edition include: * Completely new section on the basic science of pigmentation - explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system * New chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV * All clinical chapters include the latest genetic findings and advances in therapy * More than 400 color images of virtually all clinical disorders The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.
Table of Contents
| Contributors | |
| Foreword | |
| Preface | |
| Acknowledgements | |
| The Physiology of the Pigmentary System | |
| Historical and Comparative Perspectives of the Pigmentary System | |
| A History of the Science of Pigmentation | |
| Comparative Anatomy and Physiology of Pigment Cellsin Nonmammalian Tissues | |
| The Science of Pigmentation | |
| General Biology of Mammalian Pigmentation | |
| Extracutaneous Melanocytes | |
| Regulation of Melanoblast Migration and Differentiation | |
| Melanoblast Development and Associated Disorders | |
| Biogenesis of Melanosomes | |
| Melanosome Trafficking and Transfer | |
| Melanosome Processing in Keratinocytes | |
| The Regulation of Melanin Formation | |
| The Tyrosinase Gene Family | |
| Molecular Regulation of Melanin Formation: Melanosome Transporter Proteins | |
| Transcriptional Regulation of Melanocyte Function | |
| Enzymology of Melanin Formation | |
| Chemistry of Melanins | |
| The Physical Properties of Melanins | |
| Photobiology of Melanins | |
| Toxicological Aspects of Melanin and Melanogenesis | |
| Regulation of Pigment Type Switching by Agouti, Melanocortin Signaling, Attractin, and Mahoganoid | |
| Human Pigmentation: Its Regulation by Ultraviolet Light and by Endocrine, Paracrine, and Autocrine Factors | |
| Paracrine Interactions of Melanocytes in Pigmentary Disorders | |
| Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes | |
| Aging and Senescence of Melanocytes | |
| The Genetics of Melanoma | |
| The Transformed Phenotype of Melanocytes | |
| The Pathophysiology of Pigmentary Disorders | |
| An Overview of Human Skin Color and its Disorders | |
| A More Precise Lexicon for Pigmentation, Pigmentary Disorders, and "Chromatic" Abnormalities | |
| The Normal Color of Human Skin | |
| Mechanisms that Cause Abnormal Skin Color (Jean-Paul Ortonne & James J. Nordlund | |
| Disorders of Hypopigmentation, Depigmentation and Hypochromia | |
| Genetic Hypomelanoses: Disorders Characterized by Congenital White SpottingùPiebaldism, Waardenburg Syndrome, and Related Genetic Disorders of Melanocyte DevelopmentùClinical Aspects | |
| Genetic Hypomelanoses: Acquired Depigmentation | |
| Rozycki Syndrome | |
| Vitiligo Vulgaris | |
| Genetic Hypomelanoses: Generalized Hypopigmentation | |
| Oculocutaneous Albinism | |
| Albinoid Disorders | |
| Ataxia Telangiectasia (Anne-Sophie Gadenne | |
| HallermanûStreiff Syndrome | |
| Histidinemia | |
| Homocystinuria | |
| Oculocerebral Syndrome with Hypopigmentation | |
| Tietz Syndrome (Jean-Paul Ortonne | |
| Kappa-Chain Deficiency (Jean-Paul Ortonne | |
| Menkes' Kinky Hair Syndrome | |
| Phenylketonuria | |
| Genetic Hypomelanoses: Localized Hypopigmentation | |
| "Hypomelanosis of Ito" and Mosaicism | |
| Focal Dermal Hypoplasia | |
| Hypomelanosis with Punctate Keratosis of the Palms and Soles | |
| DarierûWhite Disease | |
| Nevus Depigmentosus | |
| Tuberous Sclerosis Complex | |
| Genetic Hypomelanoses: Disorders Characterized by Hypopigmentation of Hair | |
| Bird-Headed Dwarfism | |
| Down Syndrome | |
| Fisch Syndrome | |
| Premature Canities | |
| Mandibulofacial Dysostosis | |
| Myotonic Dystrophy | |
| PHC Syndrome (Böök Syndrome) | |
| Pierre Robin Syndrome | |
| Prolidase Deficiency | |
| Metabolic, Nutritional, and Endocrine Disorders Metabolic and Nutritional Hypomelanoses | |
| Hypomelanosis Associated with Endocrine Disorders | |
| Chemical, Pharmacologic, and Physical Agents Causing Hypomelanoses Chemical and Pharmacologic Agents Causing Hypomelanoses | |
| Physical Agents Causing Hypomelanoses (Jean-Philippe Lacour | |
| Infectious Hypomelanoses (Jean-Philippe Lacour | |
| Inflammatory Hypomelanoses (Jean-Philippe Lacour | |
| Hypomelanoses Associated with Melanocytic Neoplasia | |
| Miscellaneous Hypomelanoses: Depigmentation | |
| Alezzandrini Syndrome | |
| Idiopathic Guttate Hypomelanosis | |
| Leukoderma Punctata | |
| Lichen Sclerosus et Atrophicus | |
| Vagabond Leukomelanoderma | |
| VogtûKoyanagiûHarada Syndrome | |
| Westerhof Syndrome | |
| Hereditary Sclerosing Poikiloderma | |
| Mendes Da Costa Disease | |
| NaegeliûFranceschettiûJadassohn Syndrome | |
| Reticulated Acropigmentation of Dohi | |
| Reticulate Acropigmentation of Kitamura | |
| RothmundûThomson Syndrome | |
| Miscellaneous Hypomelanoses: Hypopigmentation | |
| Disseminated Hypopigmented Keratoses | |
| Hypermelanocytic Punctata et Guttata Hypomelanosis | |
| Progressive Macular Hypomelanosis | |
| Sarcoidosis | |
| Miscellaneous Hypomelanoses: Extracutaneous Loss of Pigmentation | |
| Alopecia Areata | |
| Heterochromia Irides | |
| Senile Canities | |
| Sudden Whitening of Hair | |
| Hypochromia without Hypomelanosis (Jean-Philippe Lacour | |
| Disorders of Hyperpigmentation and Hyperchromia | |
| Genetic Epidermal Syndromes: Disorders Characterized by Generalized Hyperpigmentation Adrenoleukodystrophy | |
| Familial Progressive Hyperpigmentation | |
| Fanconi Anemia | |
| Gaucher Disease | |
| Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation | |
| Berlin Syndrome | |
| Cantu Syndrome | |
| Kindler Syndrome | |
| Dermatopathia Pigmentosa Reticularis | |
| Dyschromatosis Universalis Hereditaria | |
| Epidermolysis Bullosa with Mottled Pigmentation | |
| Familial Mandibuloacral Dysplasia | |
| Hereditary Acrokeratotic Poikiloderma | |
| Erythema Dyschromicum Perstans | |
| Erythromelanosis Follicularis Faciei et Colli | |
| Erythrose Péribuccale Pigmentaire of Brocq | |
| Extracutaneous Neuroendocrine Melanoderma | |
| Felty Syndrome and Rheumatoid Arthritis | |
| Hyperpigmentation Associated with Human Immunodeficiency Virus (HIV) Infection | |
| Melanoacanthoma | |
| Phytophotodermatitis | |
| Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes: POEMS Syndrome | |
| Urticaria Pigmentosum and Mastocytosis | |
| Poikiloderma of Civatte | |
| Riehl's Melanosis | |
| Atrophoderma of Pasini et Pierini | |
| Hyperpigmentation Associated with Scleromyxedema and Gammopathy | |
| Ichthyosis Nigricans, Keratoses, and Epidermal Hyperplasia | |
| Morphea and Scleroderma | |
| Pigmentary Changes Associated with Addison Disease | |
| Pigmentary Changes Associated with Cutaneous Lymphomas | |
| Genetic Epidermal Syndromes with Café-au-lait Macules | |
| Familial Multiple Café-au-lait Spots | |
| Neurofibromatosis | |
| Neurofibromatosis 1 with Noonan Syndrome | |
| McCuneûAlbright Syndrome | |
| Segmental Neurofibromatosis | |
| SilverûRussell Syndrome | |
| Watson Syndrome | |
| Genetic Epidermal Pigmentation with Lentigines | |
| Lentigo Simplex | |
| Lentigo Senilis et Actinicus | |
| Centrofacial Lentiginosis | |
| LEOPARD Syndrome | |
| Carney Complex | |
| Other Lentiginoses | |
| Genetic Epidermal Syndromes: Localized Hyperpigmentation | |
| Anonychia with Flexural Pigmentation | |
| Incontinentia Pigmenti | |
| Periorbital Hyperpigmentation | |
| Genetic Epidermal Syndromes: Disorders of Aging | |
| Acrogeria | |
| Metageria | |
| Progeria | |
| Xeroderma Pigmentosum | |
| Werner Syndrome | |
| Congenital Epidermal Hypermelanoses | |
| Dyskeratosis Congenita | |
| Ectodermal Dysplasias | |
| Transient Neonatal Pustular Melanosis | |
| Universal Acquired Melanosis | |
| Acquired Epidermal Hypermelanoses | |
| Acanthosis Nigricans | |
| Acromelanosis Progressiva | |
| Becker Nevus | |
| Café-au-lait Spots | |
| Carcinoid Syndrome | |
| Confluent and Reticulated Papillomatosis | |
| Cutaneous Amyloidosis | |
| Dermatosis Papulosa Nigra | |
| Ephelides (Freckles) | |
| Erythema ab Igne | |
| Hypermelanosis Associated with Gastrointestinal Disorders | |
| Porphyria Cutanea Tarda | |
| CronkhiteûCanada Syndrome | |
| Hemochromatosis and Hemosiderosis | |
| Primary Biliary Cirrhosis | |
| Inflammatory Bowel Disease and Pigmentation | |
| Pigmentary Demarcation Lines | |
| DowlingûDegos Disease | |
| Acquired and Congenital Dermal Hypermelanosis | |
| Sacral Spot of Infancy | |
| Nevus of Ota | |
| Nevus of Ito | |
| Phakomatosis Pigmentovascularis | |
| Other Congenital Dermal Melanocytosis | |
| Acquired Dermal Melanocytosis | |
| CarletonûBiggs Syndrome | |
| Acquired Bilateral Nevus of Ota-like Macules (ABNOM) | |
| Blue Macules Associated with Progressive Systemic Sclerosis | |
| Mixed Epidermal and Dermal Hypermelanoses and Hyperchromias | |
| Melasma | |
| Melanosis from Melanoma | |
| Drug-induced or -related Pigmentation | |
| Disorders of Pigmentation of the Nails and Mucous Membranes | |
| The Melanocyte System of the Nail and its Disorders | |
| Pigmentary Abnormalities and Discolorations of then Mucous Membranes | |
| Benign Neoplasms of Melanocytes | |
| Common Benign Neoplasms of Melanocytes | |
| Pigmented Spindle Cell Nevi | |
| Speckled Lentiginous Nevus | |
| Melanocytic (Nevocellular) Nevi and Their Biology | |
| Rare Benign Neoplasms of Melanocytes | |
| Nevus Aversion Phenomenon | |
| Melanotic Neuroectodermal Tumor of Infancy | |
| Pilar Neurocristic Hamartoma | |
| Treatment of Pigmentary Disorders | |
| Topical Treatment of Pigmentary Disorders | |
| Chemophototherapy of Pigmentary Disorders | |
| UVB Therapy for Pigmentary Disorders | |
| Sunscreens and Cosmetics | |
| Surgical Treatments of Pigmentary Disorders | |
| Laser Treatment of Pigmentary Disorders | |
| Index | |
| Plate section | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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