The third edition of Principles of Biochemistry remains faithful to the vision of its predecessors while embracing the tremendous advances made in biochemical research since the previous edition. As always, the book presents the fundamentals of biochemistry through selected topics, emphasizing the most important recent developments and applications without abandoning the classical core of the subject. The Third Edition is thoroughly contemporary in content, design, and teaching approach, with new material and references throughout, a number of new boxes on applications, striking new graphics, and new problems drawing on real-world examples. Supplements include a superb study guide/solutions manual, an exclusive tutorial Web site based on the Chemscape Chime 3-D molecular viewer, and the new Lehninger Lecture Notebook.